Autor: |
Dr. Fangjun He, Dr. Rumeng Qu, Dr. Jie Su, Muyao Du, Dr. Junqiang Liu, Yiping Chen, Prof. Bo Wang |
Jazyk: |
angličtina |
Rok vydání: |
2020 |
Předmět: |
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Zdroj: |
ChemistryOpen, Vol 9, Iss 10, Pp 996-1000 (2020) |
Druh dokumentu: |
article |
ISSN: |
2191-1363 |
DOI: |
10.1002/open.202000178 |
Popis: |
Abstract In the classical amidation between aromatic ketones and amines, 2.0 equivalents of amines are necessarily required to gain satisfying yields. The specific role of the amine in the direct amidation already puzzled us for a long time. In this work, we disclosed that the amine acts as both reactant and catalyst. Specifically, the determination of reaction intermediates revealed the full mechanism, based on which, the introduction of one equivalent base in the amidation is showcased here that a high yield (∼95 %) can be afforded using only 1.1 equiv. of amine. |
Databáze: |
Directory of Open Access Journals |
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