Unveiling the reaction process of the amine in direct amidation of aromatic ketones in H2O

Autor:	Dr. Fangjun He, Dr. Rumeng Qu, Dr. Jie Su, Muyao Du, Dr. Junqiang Liu, Yiping Chen, Prof. Bo Wang
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	amidation reaction aromatic ketones α-ketoamide reaction mechanism NMR spectroscopy Chemistry QD1-999
Zdroj:	ChemistryOpen, Vol 9, Iss 10, Pp 996-1000 (2020)
Druh dokumentu:	article
ISSN:	2191-1363
DOI:	10.1002/open.202000178
Popis:	Abstract In the classical amidation between aromatic ketones and amines, 2.0 equivalents of amines are necessarily required to gain satisfying yields. The specific role of the amine in the direct amidation already puzzled us for a long time. In this work, we disclosed that the amine acts as both reactant and catalyst. Specifically, the determination of reaction intermediates revealed the full mechanism, based on which, the introduction of one equivalent base in the amidation is showcased here that a high yield (∼95 %) can be afforded using only 1.1 equiv. of amine.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/fc2e5afecf5b4098a56073d161104295 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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