Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair

Autor: Deepika Dogra, Suchit Ahuja, Hyun-Taek Kim, S. Javad Rasouli, Didier Y. R. Stainier, Sven Reischauer
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-017-01950-1
Popis: Zebrafish can regenerate damaged myocardial tissue but it is unclear how this is regulated. Here, the authors show that two TGF-β family members, Mstnb and Inhbaa, have opposite effects in regeneration, with mstnb overexpression or inhbaa loss-of-function causing cardiac scarring after injury.
Databáze: Directory of Open Access Journals