Oxygen Saturation Imaging Using LED-Based Photoacoustic System

Autor: Rianne Bulsink, Mithun Kuniyil Ajith Singh, Marvin Xavierselvan, Srivalleesha Mallidi, Wiendelt Steenbergen, Kalloor Joseph Francis
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Sensors, Vol 21, Iss 1, p 283 (2021)
Druh dokumentu: article
ISSN: 1424-8220
69143994
DOI: 10.3390/s21010283
Popis: Oxygen saturation imaging has potential in several preclinical and clinical applications. Dual-wavelength LED array-based photoacoustic oxygen saturation imaging can be an affordable solution in this case. For the translation of this technology, there is a need to improve its accuracy and validate it against ground truth methods. We propose a fluence compensated oxygen saturation imaging method, utilizing structural information from the ultrasound image, and prior knowledge of the optical properties of the tissue with a Monte-Carlo based light propagation model for the dual-wavelength LED array configuration. We then validate the proposed method with oximeter measurements in tissue-mimicking phantoms. Further, we demonstrate in vivo imaging on small animal and a human subject. We conclude that the proposed oxygen saturation imaging can be used to image tissue at a depth of 6–8 mm in both preclinical and clinical applications.
Databáze: Directory of Open Access Journals
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