| Autor: |
Popović Srđan, Canović Fadil, Ilić Miroljub, Rafajlovski Sašo, Dimitrijević-Srećković Vesna, Matanović Dragana, Vujović Svetlana, Đorđević Predrag, Gostiljac Draško |
| Jazyk: |
English<br />Serbian |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Vojnosanitetski Pregled, Vol 72, Iss 5, Pp 421-426 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
0042-8450 |
| DOI: |
10.2298/VSP140204055P |
| Popis: |
Background/Aim. Matrix metalloproteinase-9 (MMP-9) index is the ratio of active MMP-9 and total MMP-9 levels. It reflects the importance of MMP-9 in acute coronary syndrome (ACS). Methods. The study included 3 groups of patients (n = 87): the group 1 - non-diabetic subjects without ACS (control); the group 2 - diabetic patients with ACS [subgroups with unstable angina pectoris (UAP), myocardial infarction (MI) or reinfarction]; and the group 3 non-diabetics patients with ACS. Total and active MMP-9 were measured and used to create MMP-9 index. Results. MMP-9 index, as a marker showed good sensitivity and specificity, of ACS in diabetics, with a cut-off value over 58.2. MMP-9 was higher in the study groups than in the control one. MMP-9 correlated with ACS occurrence and type of cardiovascular event. A statistically significant difference was found among the groups according to active MMP-9 (p < 0.001). The same was found with active MMP-9 between the control and the group with MI (p < 0.001). The control was highly statistically significantly different from the group of patients with UAP (p < 0.01). Statically significant differences in MMP-9 index was found between the control and the diabetics with ACS (p < 0.001). Statistically significant difference of MMP-9 index was also found in the controls compared to the value in non-diabetic patients with ACS (p < 0.01). Conclusion. MMP-9 index may be a possible marker of atheromatous plaque rupture in diabetics. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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