| Autor: |
Albert Roso-Llorach, Xavier Serra-Picamal, Francesc X. Cos, Meritxell Pallejà-Millán, Lourdes Mateu, Antoni Rosell, Benito Almirante, Jaume Ferrer, Mercè Gasa, Carlota Gudiol, Anna Maria Moreno, Jose Luís Morales-Rull, Maria Rexach, Gladis Sabater, Teresa Auguet, Francesc Vidal, Ana Lerida, Josep Rebull, Kamlesh Khunti, Josep M. Argimon, Roger Paredes |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Global Epidemiology, Vol 4, Iss , Pp 100071- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2590-1133 |
| DOI: |
10.1016/j.gloepi.2022.100071 |
| Popis: |
Background: The changes in shield strategies, treatments, emergence variants, and healthcare pathways might shift the profile and outcome of patients hospitalized with COVID-19 in successive waves of the outbreak. Methods: We retrospectively analysed the characteristics and in-hospital outcomes of all patients admitted with COVID-19 in eight university hospitals of Catalonia (North-East Spain) between Feb 28, 2020 and Feb 28, 2021. Using a 7-joinpoint regression analysis, we split admissions into four waves. The main hospital outcomes included 30-day mortality and admission to intensive care unit (ICU). Findings: The analysis included 17,027 subjects admitted during the first wave (6800; 39.9%), summer wave (1807; 10.6%), second wave (3804; 22.3%), and third wave (4616; 27.1%). The highest 30-day mortality rate was reported during the first wave (17%) and decreased afterwards, remaining stable at 13% in the second and third waves (overall 30% reduction); the lowest mortality was reported during the summer wave (8%, 50% reduction). ICU admission became progressively more frequent during successive waves. In Cox regression analysis, the main factors contributing to differences in 30-day mortality were the epidemic wave, followed by gender, age, diabetes, chronic kidney disease, and neoplasms. Interpretation: Although in-hospital COVID-19 mortality remains high, it decreased substantially after the first wave and is highly dependent of patient's characteristics and ICU availability. Highest mortality reductions occurred during a wave characterized by younger individuals, an increasingly frequent scenario as vaccination campaigns progress. Funding: This work did not receive specific funding. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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