| Autor: |
Frederik Pagh Bredahl Kristensen, Diana Hedevang Christensen, Martin Bødtker Mortensen, Michael Maeng, Johnny Kahlert, Henrik Toft Sørensen, Reimar Wernich Thomsen |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-12 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1475-2840 |
| DOI: |
10.1186/s12933-023-01921-5 |
| Popis: |
Abstract Background Elevated triglyceride levels are a clinically useful marker of remnant cholesterol. It is unknown whether triglycerides are associated with residual cardiovascular risk in CVD-naïve patients with newly diagnosed type 2 diabetes mellitus (T2DM), who are already on statin therapy. We aimed to assess the association between triglyceride levels and risk of major cardiovascular events (MACE) in statin-treated patients with newly diagnosed T2DM managed in routine clinical care. Methods This cohort study included newly diagnosed T2DM patients without a previous diagnosis of cardiovascular disease in Northern Denmark during 2005–2017. Individual triglyceride levels while on statin treatment were assessed within 1 year after T2DM diagnosis. The primary outcome was a composite of myocardial infarction, ischemic stroke, or cardiac death (MACE). Patients were followed from one year after T2DM diagnosis until 30 April 2021, MACE, emigration, or death. We used Cox regression to compute hazard ratios (HRs) controlling for confounding factors. Results Among 27,080 statin-treated patients with T2DM (median age 63 years; 53% males), triglyceride levels were |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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