| Autor: |
Rada Ellegård, Torsten Malm, Constance G. Weismann, Eva Fernlund, Anneli Nordén Björnlert, Hanna Klang Årstrand, Katarina Ellnebo-Svedlund, Cecilia Gunnarsson |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Journal of Molecular and Cellular Cardiology Plus, Vol 10, Iss , Pp 100094- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2772-9761 |
| DOI: |
10.1016/j.jmccpl.2024.100094 |
| Popis: |
Background: Coarctation of the aorta (CoA) is a relatively common congenital heart defect. The underlying causes are not known, but a combination of genetic factors and abnormalities linked to embryonic development is suspected. There are only a few studies of the underlying molecular mechanisms in CoA. The aim of the current study was to expand our understanding of the pathogenesis of CoA by characterizing the transcriptome of the coarctation area. Methods: Tissue samples from 21 pediatric patients operated for CoA were dissected into separate biopsies consisting of the localized coarctation itself, proximal/distal tissue and ductus. RNA was sequenced to evaluate gene expression in the different biopsies. Results: We observed an activation of acute phase response in samples from the localized coarctation compared to samples from distal or proximal tissue. However, we observed even bigger differences for patient age and sex than compared to biopsy location. A cluster of genes located at 1q21, including the S100 gene family, displayed contrasting expression depending on patient sex, and appeared to affect the balance between inflammatory and interferon pathways. Biopsies from patients |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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