Aerobic training modulates T cell activation in elderly women with knee osteoarthritis

Autor: W.F. Gomes, A.C.R. Lacerda, G.E.A. Brito-Melo, S.F. Fonseca, E. Rocha-Vieira, A.A.O. Leopoldino, M.R. Amorim, V.A. Mendonça
Jazyk: angličtina
Předmět:
Zdroj: Brazilian Journal of Medical and Biological Research, Vol 49, Iss 11
Druh dokumentu: article
ISSN: 1414-431X
DOI: 10.1590/1414-431X20165181
Popis: Osteoarthritis of the knee (kOA) is a disease that mainly affects the elderly and can lead to major physical and functional limitations. However, the specific effects of walking, particularly on the immune system, are unknown. Therefore, this study aimed to analyze the effect of 12 weeks of walking (3×/week) on the leukocyte profile and quality of life (QL) of elderly women with kOA. Sixteen women (age: 67±4 years, body mass index: 28.07±4.16 kg/m2) participated in a walking program. The variables were assessed before and after 12 weeks of training with a progressively longer duration (30–55 min) and higher intensity (72–82% of HRmax determined using a graded incremental treadmill test). The QL was assessed using the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), and blood samples were collected for analysis with a cell counter and the San Fac flow cytometer. Walking training resulted in a 47% enhancement of the self-reported QL (P
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