Correction of Endothelial Dysfunction in Patients with Essential Hypertension when Using a Combination of Olmesartan/Lercanidipine and Zofenopril/Lercanidipine
| Autor: | O. V. Zimnitskaya, M. M. Petrova |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Рациональная фармакотерапия в кардиологии, Vol 12, Iss 5, Pp 536-541 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1819-6446 2225-3653 |
| DOI: | 10.20996/1819-6446-2016-12-5-536-541 |
| Popis: | Aim. To study the effect of olmesartan/lercanidipine combination and zofenopril/lercanidipine combination on the level of soluble platelet-endothelial cell adhesion molecule of the first type (sPECAM-1) in plasma in patients with essential hypertension (HT) stage II-III.Material and methods. We examined 44 people: 16 healthy volunteers (control group) and 28 patients with essential HT aged 40 to 71 years; among them 8 patients with HT II stage and 20 patients with HT III stage. Part of HP patients (subgroup 1A, n=6) received a combination of olmesartan 10- 40 mg/day + lercanidipine 5-10 mg/day; another part of HP patients (subgroup 1B, n=11) received a combination of zofenopril 7.5-30 mg/day + lercanidipine 5-10 mg/day. The examination at baseline and after 7 months included the measurement of office systolic (SBP) and diastolic (DBP) blood pressure, determination of sPECAM-1 levels in blood plasma by quantitative solid-phase enzyme immunoassay, electrocardiography, transthoracic echocardiography, complete clinical blood test, general urine analysis, biochemical blood test with lipid profile.Results. In patients with HT stage III the level of sPECAM-1 was significantly higher than in the control group (259.10 [145.36; 329.33] vs 133.18 [73.07; 170.99] pg/ml, respectively; p |
| Databáze: | Directory of Open Access Journals |
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