Cholesterol to saturated fat index (CSI), metabolic parameters and inflammatory factors among obese individuals

Autor: Mehrnaz Shakarami, Burhan Abdullah Zaman, Abdullah Sedaghat, Huda Muhammad Abbas Qassem, Yamamah Abas Zedann, Nashat Ali Soud, Mohaned Adil, Shabnam Shirvani, Naghmeh Nikbin
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Endocrine Disorders, Vol 24, Iss 1, Pp 1-10 (2024)
Druh dokumentu: article
ISSN: 1472-6823
DOI: 10.1186/s12902-024-01697-z
Popis: Abstract Background The role of dietary fat quality in promotion of cardiovascular diseases is studies before. However, the results are inconsistent. Recently, cholesterol to saturated fatty acid index (CSI) is suggested as a novel indicator of the atherogenicity and thrombogenicity potential of a diet. However, due to limited number of studies, in the current cross-sectional study, we aimed to evaluate the role of CSI in metabolic and inflammatory response among obese individuals. Methods In the current cross-sectional study 488 obese individuals aged 18–50 years old were involved in volunteer based invitation from outpatient obesity clinics. Subjects underwent anthropometric assays including weight, height, waist circumference (WC) and body composition and their fasting blood sample were obtained for biochemical assessments including blood sugar, serum lipids, hs-CRP and IL-6 concentrations by commercial kits. Physical activity was also assessed by short form of international physical activity questionnaire (IPAQ). Results According to our results, being at the top tetile of CSI was associated with higher anthropometric indices including weight, height, WC, FFM, and basal metabolic rate (BMR) compared with those at the lowest tertile (P
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