| Autor: |
Shohei Shikata, Takeshi Murata, Masayuki Yoshida, Hiromi Hashiguchi, Yukiko Yoshii, Ayumi Ogawa, Chikashi Watase, Sho Shiino, Hirokazu Sugino, Kenjiro Jimbo, Akiko Maeshima, Eriko Iwamoto, Shin Takayama, Akihiko Suto |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-023-47033-8 |
| Popis: |
Abstract Adjuvant therapy for patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, node-positive, early breast cancer (EBC) remains challenging. The prognostic significance of HER2-low positivity in these patients is not fully understood. In our retrospective study, we analyzed 647 patients with HR-positive, HER2-negative, node-positive EBC, stratifying them into three cohorts based on axillary lymph node involvement, tumor size, and characteristics. Cohort 1 included patients with either ≥ 4 positive axillary lymph nodes or 1–3 positive nodes with histological grade 3 or tumor size ≥ 5 cm. Cohort 2 consisted of patients with 1–3 positive nodes, histological grade |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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