Protective effects of an aqueous extract of Protaetia brevitarsis seulensis larvae in an ovalbumin-induced murine model of asthma
| Autor: | Hyun-Yong Kim, Hyeon-Hwa Nam, Young Hye Seo, Sueun Lee, Jin Mi Chun, Jun Lee, Jun Ho Song, Kon-Young Ji, Sung-Wook Chae, Bohye Kim, Changjong Moon, Yun-Soo Seo, Joong-Sun Kim |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Food and Agricultural Immunology, Vol 34, Iss 1 (2023) |
| Druh dokumentu: | article |
| ISSN: | 09540105 1465-3443 0954-0105 |
| DOI: | 10.1080/09540105.2023.2280502 |
| Popis: | ABSTRACTAsthma is a disease-related allergic response characterized by the accumulation of inflammatory cells in airway tissue. Protaetia brevitarsis seulensis larvae are known for their nutritional value and have been used in food; however, it is unknown whether they exert protective effects in a murine ovalbumin (OVA)-induced asthmatic model. We investigated the protective effects of an aqueous extract of P. brevitarsis seulensis larvae (PBE) against OVA-induced asthma by performing histopathological analysis and measuring inflammatory mediators in bronchoalveolar lavage fluid using enzyme-linked immunosorbent assay and flow cytometry. Asthmatic symptoms were attenuated by PBE, as indicated by decreased inflammation in lung tissue and decreased levels of inflammatory cells, inflammatory cytokines, and Th2 cell activation. Additionally, four out of six major metabolites isolated from P. brevitarsis seulensis attenuated Th2 cell activation, indicating that PBE attenuates asthmatic inflammation by regulating Th2 cell activation. Therefore, our findings support PBE as a pharmacological candidate for asthma treatment. |
| Databáze: | Directory of Open Access Journals |
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