Ageing: from inflammation to cancer

Autor: Giulia C. Leonardi, Giulia Accardi, Roberto Monastero, Ferdinando Nicoletti, Massimo Libra
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Immunity & Ageing, Vol 15, Iss 1, Pp 1-7 (2018)
Druh dokumentu: article
ISSN: 1742-4933
DOI: 10.1186/s12979-017-0112-5
Popis: Abstract Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic low-grade inflammatory process. Inflammation is also a hallmark of cancer and is widely recognized to influence all cancer stages from cell transformation to metastasis. Therefore, inflammaging may represent the biological phenomena able to couple ageing process with cancer development. Here we review the molecular and cellular pathway involved in age-related chronic inflammation along with its potential triggers and their connection with cancer development.
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje