Radical-Induced Cascade Annulation/Hydrocarbonylation for Construction of 2-Aryl-4H-chromen-4-ones

Autor:	Xinwei He, Keke Xu, Yanan Liu, Demao Wang, Qiang Tang, Wenjie Hui, Haoyu Chen, Yongjia Shang
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	cascade reaction chromen-4-ones hydrocarbonylation propargylamines Organic chemistry QD241-441
Zdroj:	Molecules, Vol 27, Iss 21, p 7412 (2022)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules27217412
Popis:	A robust metal- and solvent-free cascade radical-induced C-N cleavage/intramolecular 6-endo-dig annulation/hydrocarbonylation for the synthesis of the valuable 2-aryl-4H-chromen-4-ones is described. This practical synthesis strategy utilizes propargylamines and air as the oxygen source and green carbonylation reagent, in which propargylamines are activated by the inexpensive and available dimethyl 2,2′-azobis(2-methylpropionate) (AIBME) and (PhSe)2 as the radical initiators. This simple and green protocol features wide substrate adaptability, good functional group tolerance, and amenability to scaling up and derivatizations.
Databáze:	Directory of Open Access Journals
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