Differences in total cognition and cerebrovascular function in female breast cancer survivors and cancer-free women

Autor: Tahnee L. Downs, Eliza J. Whiteside, Gaye Foot, Dean E. Mills, Edward S. Bliss
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Breast, Vol 69, Iss , Pp 358-365 (2023)
Druh dokumentu: article
ISSN: 1532-3080
DOI: 10.1016/j.breast.2023.03.018
Popis: Reduced cognition is often reported by breast cancer patients and survivors, but the mechanisms for this decline are yet to be determined. We compared the differences in cerebrovascular function and cognition in breast cancer survivors (n = 15) and cancer-free women (n = 15) matched by age and body mass index. Participants undertook anthropometric, mood, cardiovascular, exercise performance, strength, cerebrovascular, and cognitive measurements. Transcranial Doppler ultrasound was used to measure the cerebrovascular responsiveness (CVR) to physiological (hypercapnia; 5% carbon dioxide) and psychological stimuli. Breast cancer survivors had a lower CVR to hypercapnia (21.5 ± 12.8 vs 66.0 ± 20.9%, P
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