Advantage of endoscopic papillectomy for ampullary tumors as an alternative treatment for pancreatoduodenectomy

Autor: Shohei Abe, Arata Sakai, Atsuhiro Masuda, Mika Miki, Yoshiyuki Harada, Kae Nagao, Noriko Inomata, Shinya Kohashi, Hisahiro Uemura, Shigeto Masuda, Shigeto Ashina, Masanori Gonda, Kohei Yamakawa, Masahiro Tsujimae, Yasutaka Yamada, Takeshi Tanaka, Takashi Kobayashi, Ryota Nakano, Hideyuki Shiomi, Daisuke Tsugawa, Hiroaki Yanagimoto, Tetsuo Ajiki, Maki Kanzawa, Takumi Fukumoto, Tomoo Itoh, Yuzo Kodama
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-022-19439-3
Popis: Abstract Endoscopic papillectomy for early ampullary tumors is considered a minimally invasive and useful alternative to pancreatoduodenectomy; however, its indications remain unclear. This study aimed to clarify the advantages of endoscopic papillectomy by investigating the clinical outcomes of patients who underwent endoscopic papillectomy or pancreatoduodenectomy for early ampullary tumors. Patients diagnosed with early ampullary tumors (adenoma, Tis, T1a) who underwent endoscopic papillectomy or pancreatoduodenectomy between June 2008 and October 2019 were included, and their clinical outcomes were analyzed. Seventy-four patients (34 patients with adenomas and 40 patients with adenocarcinomas) were divided into two groups, namely endoscopic papillectomy (n = 43) and pancreatoduodenectomy (n = 31). The estimated 5-year overall survival rate of all early ampullary tumors was 92%. Complete resection rate was significantly lower for endoscopic papillectomy patients versus pancreatoduodenectomy patients (48.8% vs. 100%; p
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