Coagulation disorders during treatment with cefazolin and rifampicin: rare but dangerous

Autor: I. Kouki, C. Montagner, W. Mauhin, J. London, T. Lazard, S. Grimbert, V. Zeller, O. Lidove
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Bone and Joint Infection, Vol 6, Pp 131-134 (2021)
Druh dokumentu: article
ISSN: 2206-3552
DOI: 10.5194/jbji-6-131-2021
Popis: We describe a 79-year-old man with spondylodiscitis and unknown pathogen, treated with cefazolin and rifampicin. He developed a massive digestive hemorrhage. Prothrombin time was prolonged with severe vitamin-K-dependent clotting-factor deficiency. Severe bleeding can occur during cefazolin and rifampicin use. This deficiency should be assessed before prescribing cefazolin–rifampicin and prothrombin time monitored.
Databáze: Directory of Open Access Journals