| Autor: |
Ali Kharazmkia, Javad Ghasemian Yadegari, Mohammad Mohammadian, Rehman Ali, Hossein Mahmoudvand |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of HerbMed Pharmacology, Vol 12, Iss 2, Pp 327-330 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2345-5004 |
| DOI: |
10.34172/jhp.2023.34 |
| Popis: |
Introduction: The present work aimed to assess the anti-parasitic effects of limonene (LMN) against Giardia lamblia trophozoites and cysts. Methods: Anti-Giardia activities of LMN (25, 50, and 100 μg/mL) were assessed against G. lamblia cysts and trophozoites for 15-360 minutes. The effects of LMN on the apoptosis stimulation G. lamblia parasites were determined by colorimetric protease assay. Results: Giardia trophozoites were more sensitive to LMN than cysts. The best effect of LMN was seen at 100 μg/mL. LMN markedly triggered caspase-3 activity by 10.2%, 25.3%, and 36.1%, respectively (P < 0.001). Conclusion: We found the potent in vitro anti-giardia activity of LMN against G. lamblia parasites with the maximum activity at 50 and 100 μg/mL. However, additional surveys are necessary to reveal the specific efficacy, mechanisms, and safety of LMN. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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