| Autor: |
Caroline Marcondes Ferreira, Tania Rubia Flores da Rocha, Evandro Oliveira Souza, Flair Jose Carrilho, Elbio Antonio D'amico, Alberto Queiroz Farias |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Annals of Hepatology, Vol 24, Iss , Pp 100374- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1665-2681 |
| DOI: |
10.1016/j.aohep.2021.100374 |
| Popis: |
Introduction: Thrombin generation (TG) is normal or elevated in patients with cirrhosis when tested in the presence of thrombomodulin (TM), the activator of the main natural anticoagulant protein C. However, the relationship between TG with bleeding has been little explored in literature. Aims: To assess the relation among TG potential, measured without and in presence of TM, INR and the occurrence of bleeding after endoscopic band ligation of esophageal varices. Patients and Methods: 97 consecutive patients with cirrhosis were prospectively included (58 men; 54±10 years) and divided into two groups INR< 1.5 (n=72) or INR ≥1.5 (n=25). 46 healthy individuals were tested as controls. Endogenous thrombin potential (ETP) was measured without and with the addition of TM. Results: ETP measured without TM was reduced in patients with cirrhosis when compared to controls, but no significant difference was found between the INR< 1.5 and INR ≥1.5 groups (1,250±315.7 versus 1,186±238 nmol/L x min; p= 0.3572). After addition of TM, both groups generated thrombin comparable to controls (INR ≥1.5: 965.9±232.3; INR |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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