DEVELOPMENT OF METHOD FOR DETERMINATION OF INTRINSIC VISCOSITY OF INJECTABLE DRUG WITH CHONDROITIN SULFATE

Autor:	K. R. Saveleva, L. V. Pesanova, V. N. Shestakov, S. V. Poliyakov
Jazyk:	ruština
Rok vydání:	2019
Předmět:	chondroitin sulfate drug intramuscular solution reduced viscosity intrinsic viscosity Pharmaceutical industry HD9665-9675
Zdroj:	Разработка и регистрация лекарственных средств, Vol 0, Iss 4, Pp 154-158 (2019)
Druh dokumentu:	article
ISSN:	2305-2066 2658-5049
Popis:	The article presents data on the development of a technique for determination of intrinsic viscosity of injectable drug with chondroitin sodium sulfate. A 0.2 M solution of sodium chloride was use as a solvent to eliminate polyelectrolyte swelling. The calculated viscosity of the test solutions was determinate in the concentration range of chondroitin sulfate 4.5-20 mg /ml. The value of the intrinsic viscosity, determined for each of the tested preparations, was in the range 0.03-0.042 m3/kg.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/fb3ed8c8b27a4384a19c48285875eb2c Zobrazit plný text záznamu View record in DOAJ