Efficacy and influential factors of hematoporphyrin monomethyl ether mediated photodynamic therapy in the treatment for port-wine stains

Autor: Yanlan Yu, Shichong Tang, Youquan Luo, Mengxue Zheng, Wanzhen He, Yueling Liu, Yan Xiao, Rui Yin
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Photodiagnosis and Photodynamic Therapy, Vol 45, Iss , Pp 103933- (2024)
Druh dokumentu: article
ISSN: 1572-1000
DOI: 10.1016/j.pdpdt.2023.103933
Popis: Backgrounds: Hematoporphyrin monomethyl ether mediated photodynamic therapy (HMME-PDT) has emerged as an alternative approach for port-wine stain (PWS), which was primarily treated with pulsed dye laser (PDL). This study was aimed to evaluate the efficacy and safety of HMME-PDT for PWS and to explore influential factors on the efficacy. Methods: A total of 254 patients were enrolled. Patients received an intravenous injection of HMME at 5 mg/kg. Lesion areas were irradiated with 532-nm light for 20–25 min. Efficacy was assessed according to fading of lesions and graded as excellent (≥90 %), good (60 %–89 %), fair (20 %–59 %), or poor (
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