| Autor: |
J. Gutiérrez-Cuevas, D López-Cifuentes, AS Sandoval-Rodríguez, AO Vázquez-Esqueda, JS Rodríguez-Sanabria, J Armendáriz-Borunda |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Annals of Hepatology, Vol 27, Iss , Pp 100860- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1665-2681 |
| DOI: |
10.1016/j.aohep.2022.100860 |
| Popis: |
Introduction and Objectives: Metabolic associated fatty liver disease (MAFLD) is characterized by hepatic steatosis with the following three metabolic conditions: obesity/overweight, diabetes and metabolic dysregulation, either alone or in combination. Pirfenidone (PFD) has anti-inflammatory, antioxidant, and anti-fibrotic effects. The aim of this study was to investigate the effects of PFD in mice with MAFLD induced by high-fat/high-carbohydrate (HFHC) diet. Materials and methods: At the age of 6-7 weeks, six male C57BL/6 J mice were fed with a normal diet (ND, 18% kcal from fat food) and twelve with HFHC (60% kcal from fat food and drinking water with 42 g/L of carbohydrates: 55% fructose and 45% sucrose) diet for 20 weeks; at 10 weeks of feeding, six mice with HFHC diet were administered PFD (300 mg/kg/day) by gavage. An insulin tolerance test was performed, and data analysis were performed using SPSS. The trial was approved by the research ethics committee. Results: All HFHC mice showed an increase in body weight and visceral fat accumulation (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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