Genetically predicted circulating linoleic acid levels and risk of osteoarthritis: a two-sample mendelian randomization study

Autor:	Wen Yang, Wenwu Xiao, Hailong Liu
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Osteoarthritis Linoleic acid Mendelian randomization Diseases of the musculoskeletal system RC925-935
Zdroj:	BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-10 (2024)
Druh dokumentu:	article
ISSN:	1471-2474
DOI:	10.1186/s12891-024-08018-4
Popis:	Abstract Objectives This study aimed to provide insight into the effect of genetically predicted linoleic acid (LA) levels on osteoarthritis (OA). Methods The LA dataset was obtained from the UK Biobank (UKBB) consortium and contained 114,999 samples. The OA discovery dataset was derived from MRC-IEU consortium and included 38,472 cases and 424,461 controls. The OA validation set was derived from a summary-level genome-wide association study (GWAS) and included 39,427 cases and 378,169 controls. Genetic variants strongly associated with LA (p
Databáze:	Directory of Open Access Journals
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