FERONIA functions through Target of Rapamycin (TOR) to negatively regulate autophagy

Autor: Ping Wang, Natalie M. Clark, Trevor M. Nolan, Gaoyuan Song, Olivia G. Whitham, Ching-Yi Liao, Christian Montes-Serey, Diane C. Bassham, Justin W. Walley, Yanhai Yin, Hongqing Guo
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Frontiers in Plant Science, Vol 13 (2022)
Druh dokumentu: article
ISSN: 1664-462X
DOI: 10.3389/fpls.2022.961096
Popis: FERONIA (FER) receptor kinase plays versatile roles in plant growth and development, biotic and abiotic stress responses, and reproduction. Autophagy is a conserved cellular recycling process that is critical for balancing plant growth and stress responses. Target of Rapamycin (TOR) has been shown to be a master regulator of autophagy. Our previous multi-omics analysis with loss-of-function fer-4 mutant implicated that FER functions in the autophagy pathway. We further demonstrated here that the fer-4 mutant displayed constitutive autophagy, and FER is required for TOR kinase activity measured by S6K1 phosphorylation and by root growth inhibition assay to TOR kinase inhibitor AZD8055. Taken together, our study provides a previously unknown mechanism by which FER functions through TOR to negatively regulate autophagy.
Databáze: Directory of Open Access Journals