The study of cross-reactivity of therapeutic drugs based on monoclonal antibodies on human tissues: basic approaches and methodological techniques

Autor:	T. Y. Ostroukhova, V. A. Ivanov, E. L. Morozova, R. A. Ivanov
Jazyk:	ruština
Rok vydání:	2018
Předmět:	исследование тканевой перекрестной реактивности (кросс-реактивности) препарата (tcr) моноклональное антитело иммуногистохимический (игх) анализ tissue cross-reactivity (tcr) study monoclonal antibody immunohistochemical (ihc) assay Biotechnology TP248.13-248.65 Medicine
Zdroj:	Биопрепараты: Профилактика, диагностика, лечение, Vol 16, Iss 4, Pp 237-244 (2018)
Druh dokumentu:	article
ISSN:	2221-996X 2619-1156
Popis:	Tissue cross-reactivity (TCR) studies are screening immunohistochemical (IHC) assays, usually conducted on frozen human and animal tissues. This study is obligatory for getting the permission for clinical trials in Russia for all innovative therapeutic products based on monoclonal antibodies or antibody-like molecules that contain complementarity-determining region (CDR). In this article are represented approaches and methodical features for successful conduction of tissue cross-reactivity studies with examples from own authors’ experience.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/afafe146eee74a70b1e8760e42a0681c Zobrazit plný text záznamu View record in DOAJ