Generation of a human induced pluripotent stem cell line (VRFi001-A) from orbital adipose tissue of a bilateral retinoblastoma patient with heterozygous RB1 gene deletion

Autor: Ambily Vincent, Vikas Khetan, Pukhraj Rishi, Ganesan Suganeswari, Subramanian Krishnakumar, Uma Maheswari Krishnan, Sowmya Parameswaran
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Stem Cell Research, Vol 29, Iss , Pp 42-45 (2018)
Druh dokumentu: article
ISSN: 1873-5061
DOI: 10.1016/j.scr.2018.03.012
Popis: Retinoblastoma (RB) is a pediatric intraocular tumor caused by mutations in retinoblastoma (RB1) gene. We have generated induced pluripotent stem cell line VRFi001-A from a bilateral retinoblastoma patient with heterozygous RB1 gene deletion. The iPSC line VRFi001-A retained the mutation and expressed pluripotency markers, had a normal karyotype and was capable of trilineage differentiation.
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