IL-6 and D-dimer Levels at Admission Predict Cardiac Injury and Early Mortality during SARS-CoV-2 Infection
| Autor: | Kexin Peng, Beibei Du, Daoyuan Si, Lina Jin, Bo Yang, Neil Johnson, Lujia Ni, Qian Zhang, Mohammed Ali Azam, Patrick F. H. Lai, Slava Epelman, Kumaraswamy Nanthakumar, Ping Yang |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Cardiovascular Innovations and Applications, Vol 9, Iss 1, p 975 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2009-8782 2009-8618 |
| DOI: | 10.15212/CVIA.2024.0009 |
| Popis: | Background: We previously described the mortality associated with cardiac injury in patients with coronavirus disease 2019 (COVID-19). The activation of immune and thrombotic biomarkers at admission, and their ability to predict cardiac injury and mortality patterns in COVID-19, remains unclear. Methods: This retrospective cohort study included 170 patients with COVID-19 with cardiac injury at the time of admission to Tongji Hospital in Wuhan between January 29, 2020, and March 8, 2020. The temporal evolution of inflammatory cytokines, coagulation markers, clinical treatment, and mortality were analyzed. Continuous variables are expressed as median (interquartile range). The Mann-Whitney test was used for two-group comparisons, whereas the Kruskal-Wallis test was used for comparisons among three groups. Categorical variables are expressed as proportions and percentages, and Fisher’s exact test was used to compare differences. A multivariate regression model was used to predict in-hospital death. A simple linear regression analysis was applied to examine the correlation between baseline biomarkers and peak cTnI levels. Results: Of the 170 patients, 60 (35.3%) died early ( |
| Databáze: | Directory of Open Access Journals |
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