Clinical, physiological, and radiological different phenotypes of COPD patients

Autor: Islam Galal, Zeinab Rabie, Shazly Ahmed, Ahmed Hamdy Mhsb, Samah Kotb
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: The Egyptian Journal of Bronchology, Vol 17, Iss 1, Pp 1-9 (2023)
Druh dokumentu: article
ISSN: 2314-8551
DOI: 10.1186/s43168-023-00232-3
Popis: Abstract Background COPD is a heterogeneous lung disorder with multiple phenotypes and endotypes. This study aimed to identify the diverse clinical, physiological, and radiological phenotypes of COPD. Moreover, to provide whether there was a possible relation between FEV1%, FVC%, and FEV1/FVC ratio, [both before and after broncho-dilation with the diameters of the airway at three diverse levels throughout both inspiratory and expiratory phases of respiration]. Results This study included 50 cases, that were classified according to the radiological phenotypes into 5 groups [29 cases (58%) were mild [centrilobular emphysema) CLE)], 8 cases (16%) were moderate CLE, 5 cases (10%) were [confluent emphysema (CON)], 5 cases (10%) were [advanced destructive emphysema (ADE)] and 3 cases (6%) were [para septal emphysema (PSE)]. There was no considerable variance in the frequency of COPD clinical phenotypes among the diverse radiological phenotypes. There was a moderate positive correlation between the predicted FEV1% and the corresponding inter-luminal diameter at the selected levels (RB1, and LB3) in the inspiratory phase of respiration (P
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