Sjögren’s syndrome positive for isolated anti-Ro52/SS-A antibody and anti-centromere antibody
| Autor: | Hideki Nakamura, Masako Tsukamoto, Kinya Nagata, Yosuke Nagasawa, Kumiko Akiya, Hirotake Inomata, Masahiro Nishihara, Shin-Ya Asatani, Noboru Kitamura, Hisataka Kitano, Jun Shoji, Yu Iwabuchi, Toshiyuki Ishige, Hiroyuki Hao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Journal of International Medical Research, Vol 52 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1473-2300 03000605 |
| DOI: | 10.1177/03000605241293986 |
| Popis: | This current case report describes a Japanese woman in her 80s with xerostomia who presented with salivary gland dysfunction. She was positive for isolated anti-Ro52/SS-A antibody as determined by a chemiluminescent enzyme immunoassay and positive on a fluorescence enzyme immunoassay that recognizes both Ro52 and Ro60 antigens. A high serum concentration of anti-Ro52/SS-A antibody was determined by an enzyme-linked immunosorbent assay. A high anti-centromere antibodies (ACA) titre was also observed. Although Raynaud’s phenomenon or a high serum immunoglobulin G concentration were not observed, Masson-trichrome staining of the patient’s labial salivary glands showed considerable fibrosis. Her serum type I and type II interferon concentrations were normal. The present patient is the first with Sjögren’s syndrome (SS) to exhibit isolated anti-Ro52/SS-A antibody and ACA without anti-Ro60/SS-A antibody. This current case report presents her case together with those of four other SS patients who were positive for isolated anti-Ro52/SS-A antibody. The SS literature also includes cases positive for ACA and describes clinical characteristics. The other four SS patients with isolated anti-Ro52/SS-A antibody described here had no ACA; interstitial pneumonia and polyneuropathy were observed in these cases, although there was no consistent tendency regarding types I and II interferon. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|