Performance of Risk Scores in Predicting Infective Endocarditis in Patients with Staphylococcus aureus Bacteraemia in a Prospective Asian Cohort

Autor: Jinghao Nicholas Ngiam, Matthew Chung Yi Koh, Sophia Archuleta, Dale Fisher, Louis Yi-Ann Chai, Ching-Hui Sia, William K. F. Kong, Paul Anantharajah Tambyah
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Clinical Medicine, Vol 13, Iss 10, p 2947 (2024)
Druh dokumentu: article
ISSN: 2077-0383
DOI: 10.3390/jcm13102947
Popis: Background: Several risk scores have been derived to predict the risk of infective endocarditis (IE) amongst patients with Staphylococcus aureus bacteraemia (SAB), which helps to guide clinical management. Methods: We prospectively studied 634 patients admitted with SAB. The cohort was stratified into those with or without IE, and the PREDICT Day 1, Day 5 and VIRSTA scores were tabulated. Area under the receiver operating characteristic (AUC) curves were constructed to compare the performance of each score. Results: Of the 634 patients examined, 36 (5.7%) had IE. These patients were younger (51.6 ± 20.1 vs. 59.2 ± 18.0 years, p = 0.015), tended to have community acquisition of bacteraemia (41.7% vs. 17.9%, p < 0.001), and had persistent bacteraemia beyond 72 h (19.4% vs. 6.0%, p = 0.002). The VIRSTA score had the best performance in predicting IE (AUC 0.76, 95%CI 0.66–0.86) compared with PREDICT Day 1 and Day 5. A VIRSTA score of Conclusions: Overall, the risk scores performed well in our Asian cohort. If applied, 23.5% of the cohort with a VIRSTA ≥ 3 would require TEE, and a score of
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