Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk

Autor: Lucas H. Ting, Shirin Feghhi, Nikita Taparia, Annie O. Smith, Ari Karchin, Esther Lim, Alex St. John, Xu Wang, Tessa Rue, Nathan J. White, Nathan J. Sniadecki
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-09150-9
Popis: Platelet aggregates generate contractile forces that contribute to their cohesion and adhesion. Here, Ting et al. develop a microfluidic device to measure contractile forces generated by platelet aggregates, and find it can detect the response of platelets to pharmacological agents and predict bleeding risk in trauma patients.
Databáze: Directory of Open Access Journals