A CpG island-encoded mechanism protects genes from premature transcription termination

Autor: Amy L. Hughes, Aleksander T. Szczurek, Jessica R. Kelley, Anna Lastuvkova, Anne H. Turberfield, Emilia Dimitrova, Neil P. Blackledge, Robert J. Klose
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-36236-2
Popis: Here the authors discover that SET1 complexes function as transcription anti-termination factors that bind to CpG islands and protect low to moderately transcribed genes from the pervasive termination activity of the ZC3H4 complex.
Databáze: Directory of Open Access Journals