Blood pH and urinary uric acid-creatinine ratio in newborns with asphyxia
| Autor: | Sally Palit, Rocky Wilar, Ari Runtunuwu, Julius Lolombulan |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Paediatrica Indonesiana, Vol 55, Iss 6, Pp 352-6 (2016) |
| Druh dokumentu: | article |
| ISSN: | 0030-9311 2338-476X |
| DOI: | 10.14238/pi55.6.2015.352-6 |
| Popis: | Background Asphyxia is one of the leading causes of death in the world. Prematurity (28%), sepsis (26%), and asphyxia (23%) are the most common causes of death in newborns. In Indonesia, the newborn mortality incidence is 82 per 1,000 live births. Blood pH is a routine laboratory examination to diagnose newborn asphyxia, but it is preferrable to avoid such invasive procedures in newborns. An examination of urinary uric acid-creatinine (UA/ Cr) ratio may be useful as an alternative method for diagnosis of asphyxia. Hypoxia causes anaerobic metabolism which will increase the blood acidity, while creatinine will decline as a result of incomplete renal function in newborns. Objective To assess for a possible correlation between blood pH and urinary UA/Cr ratio in newborn asphyxia. MethodsWe conducted an observational, cross-sectional study in Prof. Dr. R. D. Kandou Hospital, Manado, North Sulawesi, from November 2013 to April 2014. Subjects were full term newborns with asphyxia. Blood pH and urinary UA/Cr ratio were compared with Pearson’s correlation test. Data was analyzed with SPSS version 22 software and P values |
| Databáze: | Directory of Open Access Journals |
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