Perampanel-associated Psychiatric Problems

Autor: Anil Kakunje, Shivanand Pai, S. Raghavendra
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Archives of Medicine and Health Sciences, Vol 12, Iss 1, Pp 114-115 (2024)
Druh dokumentu: article
ISSN: 2321-4848
2321-6085
DOI: 10.4103/amhs.amhs_228_23
Popis: Perampanel is a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptor antagonist used in the management of seizure disorder. Management of uncontrolled seizures is a challenging task. Perampanel is a recent antiepileptic which comes with a warning of causing behavioral and psychological adverse effects. Here, the authors report an interesting case where the perampanel was started to control refractory seizures and the person developed severe behavioral disturbances. The condition warranted a psychiatry referral, and the problems subsided after stopping perampanel. Clinicians need to be vigilant about perampanel-associated behavioral and psychiatric problems which can become a serious clinical concern.
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