Bilateral lower extremity amputation in a transgender female on estrogen therapy suffering from recurrent, medication-resistant arterial thrombi

Autor: Mitchell C. McDaniels, BS, Patrick D. Conroy, MD, Philip M. Batista, MD
Jazyk: angličtina
Rok vydání: 2025
Předmět:
Zdroj: Journal of Vascular Surgery Cases and Innovative Techniques, Vol 11, Iss 1, Pp 101655- (2025)
Druh dokumentu: article
ISSN: 2468-4287
DOI: 10.1016/j.jvscit.2024.101655
Popis: This case report presents a 40-year-old transgender female with a history of gender-affirming hormone therapy who experienced recurrent, medication-resistant arterial thrombi leading to bilateral lower extremity amputations. Despite multiple endovascular and surgical interventions, including bypass grafting and catheter-directed thrombolysis, the patient developed recurrent thrombotic events even while on anticoagulation therapy. Hematologic evaluation for coagulopathy was unremarkable. The case underscores the need for greater understanding of gender-affirming hormone therapy’s long-term cardiovascular effects while highlighting the challenges in managing arterial thrombosis in transgender patients. Further research is required to guide optimal anticoagulation strategies in this population.
Databáze: Directory of Open Access Journals