RNA sequencing and bioinformatics analysis of circular RNAs in asphyxial newborns with acute kidney injury

Autor: Jing‐Jing Pan, Yang Yang, Xiao‐Qing Chen, Jia Shi, Mu‐Zi Wang, Mei‐Ling Tong, Xiao‐Guang Zhou
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Kaohsiung Journal of Medical Sciences, Vol 39, Iss 4, Pp 337-344 (2023)
Druh dokumentu: article
ISSN: 2410-8650
1607-551X
DOI: 10.1002/kjm2.12644
Popis: Abstract As one kind of novel noncoding RNA, circular RNAs (circRNAs) are involved in different biological processes. Although growing evidences have supported the important role of circRNAs in renal diseases, the mechanism remains unclear in neonatal acute kidney injury (AKI). High‐throughput sequencing analysis was used to investigate the expression of circRNAs between hypoxia‐induced AKI neonates and controls. Bioinformatics analysis was conducted to predict the function of differentially expressed circRNAs. Finally, the differentially expressed circRNAs were screened and determined by quantitative real‐time PCR (qPCR). (1) A total of 296 differentially expressed circRNAs were identified (Fold change >2 and p
Databáze: Directory of Open Access Journals
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