Clinical application of liquid biopsy in cancer patients

Autor:	Chieh-Min Chang, Kuei-Ching Lin, Nien-En Hsiao, Wei-An Hong, Chia-Yu Lin, Ta-Chih Liu, Ya-Sian Chang, Jan-Gowth Chang
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Liquid biopsy Clonal hematopoiesis Somatic mutation Germline mutation Pathogenic/likely pathogenic variant Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	BMC Cancer, Vol 22, Iss 1, Pp 1-9 (2022)
Druh dokumentu:	article
ISSN:	1471-2407
DOI:	10.1186/s12885-022-09525-0
Popis:	Abstract Background This study was to determine the prevalence and clinical significance of clonal hematopoiesis (CH)-related variants, and somatic and germline mutations in cancer patients and healthy individuals. Methods We performed next-generation sequencing of 275 cancer-related genes be-tween plasma and white blood cells in 92 cancer patients and 47 controls without cancer. Blood samples were recruited from May 2017 to July 2021, and blood cancer patients were excluded. For all statistical analysis in this study, p
Databáze:	Directory of Open Access Journals
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