| Autor: |
Mitsunori Ushigome, Hideaki Shimada, Tomoaki Kaneko, Yasuyuki Miura, Yasuo Nagashima, Takayuki Suzuki, Satoru Kagami, Akiharu Kurihara, Kimihiko Funahashi |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of the Anus, Rectum and Colon, Vol 6, Iss 4, Pp 264-273 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2432-3853 |
| DOI: |
10.23922/jarc.2022-010 |
| Popis: |
Objectives: We evaluated the prognostic impact of a novel C-reactive protein (CRP) cut-off value (0.6 mg/dl) and carcinoembryonic antigen (CEA)/carbohydrate antigen 19-9 (CA19-9) in stage II/III colorectal cancer. Methods: Four hundred ninety-eight patients with stage II (n = 275) or stage III (n = 223) colorectal cancer, surgically treated between January 2010 and December 2016, were analyzed. The optimal CRP cut-off value was fixed at 0.6 mg/dl to predict recurrence based on the receiver operating characteristic curve. Prognostic factors, including CRP/CEA/CA19-9 status, for relapse-free survival (RFS) were evaluated by multivariate analysis. Results: Recurrent rates were 15% and 32% in stages II and III, respectively. In stage II, CRP, CEA, and CA19-9 were not significant prognostic factors for RFS. In stage III, the RFS of the low CRP group was significantly better than that of the high CRP group (p = 0.002). In stage III, the RFS of CRP(−)/CEA(−) or CRP(−)/CA19-9(−) was significantly better than the other group, as opposed to the RFS of the CEA(−)/CA19-9(−) group that was not. The CRP(−)/CEA(−)/CA19-9(−) group recurrence rate in stage III was significantly better than the CRP(+)/CEA(−)/CA19-9(−) group (20% vs. 50%, p = 0.006). Multivariate analysis revealed that CRP(−)/CEA(−)/CA19-9(−) (p = 0.04) and non-T4 (p < 0.001) were good independent prognostic factors in stage III. The CRP(−)/CEA(−)/CA19-9(−)/non-T4 group recurrence rate in stage III was 11% (8 out of 73). Conclusions: In stage III, the CRP(−)/CEA(−)/CA19-9(−)/non-T4 group is favorable risk for recurrence. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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