Tumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses
| Autor: | Zhijuan Yang, Yujie Zhu, Ziliang Dong, Wei Li, Nailin Yang, Xianwen Wang, Liangzhu Feng, Zhuang Liu |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 83645934 |
| DOI: | 10.1038/s41467-021-24604-9 |
| Popis: | Radiofrequency ablation (RFA) is a minimally invasive tumor ablation method, however incomplete ablation and the induction of an immunosuppressive microenvironment limit its efficacy in the clinic. Here the authors design a pH-responsive lipoxidase-loaded nanoreactor, that by triggering ferroptosis and anti-tumor immunity, amplify the therapeutic benefits of RFA in preclinical models. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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