Successful Reversal of Diabetes by Single Donor Isologous Islet Transplantation in a Mouse Model
| Autor: | C. K. Leow, D. W. R. Gray, P. J. Morris |
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| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: | |
| Zdroj: | Cell Transplantation, Vol 6 (1997) |
| Druh dokumentu: | article |
| ISSN: | 0963-6897 1555-3892 09636897 |
| DOI: | 10.1177/096368979700600410 |
| Popis: | A method for isolating mouse islets which consistently gives a high yield with good purity is described. Using a bovine serum albumin gradient, the mean yield of islets per pancreas is 425 (SEM ± 15) with a consistent purity of over 90%. Single donor to single recipient of islets transplanted under the renal capsule restores normoglycemia in the diabetic recipients within 2 to 5 days of transplantation. |
| Databáze: | Directory of Open Access Journals |
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