Common DNA methylation dynamics in endometriod adenocarcinoma and glioblastoma suggest universal epigenomic alterations in tumorigenesis

Autor: Jennifer A. Karlow, Benpeng Miao, Xiaoyun Xing, Ting Wang, Bo Zhang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-02094-1
Popis: Jennifer Karlow et al. characterize the DNA methylation changes in two unrelated cancer types. They find that both cancers show methylation changes in regulatory regions corresponding to the cancer’s tissue of origin, suggesting that loss of cellular identity may be an important step in tumorigeneses shared across cancers.
Databáze: Directory of Open Access Journals