| Autor: |
Namasivayam Ambalavanan, George T El-Ferzli, Claire Roane, Robert Johnson, Waldemar A Carlo |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 4, Iss 2, p e4312 (2009) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0004312 |
| Popis: |
We have shown earlier that inhaled nitric oxide (iNO) administered by oxygen hood reduces pulmonary hypertension in an animal model (J Perinatol 2002; 22:50-6). Our objective in this study was to determine feasibility of iNO by oxygen hood in neonates with elevated alveolar-arterial oxygen gradients (A-aDO(2)).Masked randomized controlled pilot trial. Inclusion criteria were: gestation>or=34 weeks, age100 torr, while oxygenation was unchanged in the controls. Methemoglobinemia and other adverse effects were not noted in any infant. Environmental levels of NO and NO(2) were minimal (0.3 m from the hood.Administration of iNO by oxygen hood is feasible. Larger randomized controlled trials are required to measure the efficacy and determine an appropriate target population for this technique.ClinicalTrials.gov NCT00041548. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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