Total Asymmetric Synthesis of Monosaccharides and Analogues
| Autor: | Inmaculada Robina, Ana T. Carmona, Antonio J. Moreno-Vargas, Elena Moreno-Clavijo |
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| Jazyk: | German<br />English<br />French |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | CHIMIA, Vol 65, Iss 1-2 (2011) |
| Druh dokumentu: | article |
| ISSN: | 0009-4293 2673-2424 |
| DOI: | 10.2533/chimia.2011.85 |
| Popis: | Since the discovery of the 'formose reaction' by Butlerow,[1] total synthesis of carbohydrates has undergone rapid development. The most important methods for the asymmetric synthesis of monosaccharides and analogues of biological importance are presented. Nowadays any natural and non-natural monosaccharide can be prepared pure in both enantiomeric forms starting from inexpensive starting materials. Metal-based asymmetric catalysis and organocatalysis have been successfully applied, alone or in combination with chemoenzymatic methods. Alternative methods rely upon substrate- or reagent- controlled diastereo- and enantioselective reactions. Suitably protected carbohydrates have been prepared by total synthesis, thus allowing their direct use in the preparation of oligosaccharides and analogues.[2] |
| Databáze: | Directory of Open Access Journals |
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