Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases

Autor: A. Emilia Arguello, Ang Li, Xuemeng Sun, Tanner W. Eggert, Elisabeth Mairhofer, Ralph E. Kleiner
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-31876-2
Popis: Kleiner and co-workers profile RNA 5-methylcytidine (m5C) dioxygenase enzymes using an activity-based metabolic probing strategy. They reveal ALKBH1 as the major 5-formylcytidine (f5C) writer and characterize modification sites across mRNA and tRNA.
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