Circulating Naturally-Occurring Anticoagulants before Treatment and after Recovery from SARS-CoV-2 Infection in Ghana

Autor: Charles Nkansah, Lawrence D. Agyemang, Felix Osei-Boakye, Samuel K. Appiah, Kofi Mensah, Gabriel Abbam, Simon B. Bani, Samira Daud, Hisham A. Osumanu, Charles A. Derigubah, Dorcas Serwaa, Francis A. Apodola, Ezekiel B. Ackah, Michael O. Tetteh, Nurain Abdul-Kareem, Fatima P. Abubakar, Candy A. E. Wilson, David A. Afrifa, Yasir Ishaq, Ruth A. A. Wedam, Fremah P. Agyeman-Duah, Kingsford O. Appiah, Yeduah Quansah, Peace E. Agbadza, Clement B. Dagungong, Michael Owusu, Felix E. Chukwurah
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: SciMedicine Journal, Vol 4, Iss 4, Pp 142-154 (2022)
Druh dokumentu: article
ISSN: 2704-9833
DOI: 10.28991/SciMedJ-2022-04-04-01
Popis: Background: Disturbance in naturally-occurring anticoagulants may contribute to the hypercoagulable state in COVID-19. This study determined the plasma antigen levels of protein C (PC), protein S (PS), antithrombin-III (AT-III), and thrombomodulin (TM) before treatment and after recovery from COVID-19. Materials and Methods: This cross-sectional study, conducted from February to August 2022 at Kumasi South Hospital, recruited sixty-five RT-PCR-confirmed COVID-19 participants. A venous blood sample was taken for full blood count (FBC) analysis using a 3-part fully automated haematology analyzer, and PC, PS, AT-III, and TM antigen levels measured using ELISA. The data were analyzed using SPSS version 26.0. P
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