Should non-bacteraemic patients with a colonized catheter receive antimicrobial therapy?
| Autor: | V. De Egea, M. Guembe, A. Rodríguez-Borlado, M.J. Pérez-Granda, C. Sánchez-Carrillo, E. Bouza |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | International Journal of Infectious Diseases, Vol 62, Iss C, Pp 72-76 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1201-9712 1878-3511 |
| DOI: | 10.1016/j.ijid.2017.07.014 |
| Popis: | Objectives: The impact of antimicrobial therapy on the outcomes of patients with colonized catheters and no bacteraemia has not been assessed. This study assessed whether targeted antibiotic therapy is related to a poor outcome in patients with positive cultures of blood drawn through a non-tunnelled central venous catheter (CVC) and without concomitant bacteraemia. Methods: This was a retrospective study involving adult patients with positive blood cultures drawn through a CVC and negative peripheral vein blood cultures. Patients were classified into two groups: those with clinical improvement and those with a poor outcome. These two groups were compared. The outcome was considered poor in the presence of one or more of the following: death, bacteraemia or other infection due to the same microorganism, and evidence of catheter-related bloodstream infection. Results: A total of 100 patients were included (31 with a poor outcome). The only independent predictors of a poor outcome were a McCabe and Jackson score of 1–2 and a median APACHE score of 5. No association was found between the use of targeted antimicrobial therapy and a poor outcome when its effect was adjusted for the rest of the variables. Conclusions: This study showed that antimicrobial therapy was not associated with a poor outcome in non-bacteraemic patients with positive blood cultures drawn through a CVC. |
| Databáze: | Directory of Open Access Journals |
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