Natural killer cell-derived exosomes for cancer immunotherapy: innovative therapeutics art

Autor: Zahra Hatami, Zahra Sadat Hashemi, Mohamad Eftekhary, Ala Amiri, Vahid Karpisheh, Kaveh Nasrollahi, Reza Jafari
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Cancer Cell International, Vol 23, Iss 1, Pp 1-18 (2023)
Druh dokumentu: article
ISSN: 1475-2867
DOI: 10.1186/s12935-023-02996-6
Popis: Abstract Chimeric antigen receptor natural killer cells (CAR-NK) promote off-the-shelf cellular therapy for solid tumors and malignancy.However,, the development of CAR-NK is due to their immune surveillance uncertainty and cytotoxicity challenge was restricted. Natural killer cell-derived exosome (NK-Exo) combine crucial targeted cellular therapies of NK cell therapies with unique non-toxic Exo as a self-origin shuttle against cancer immunotherapy. This review study covers cytokines, adoptive (autologous and allogenic) NK immunotherapy, stimulatory and regulatory functions, and cell-free derivatives from NK cells. The future path of NK-Exo cytotoxicity and anti-tumor activity with considering non-caspase-independent/dependent apoptosis and Fas/FasL pathway in cancer immunotherapy. Finally, the significance and implication of NK-Exo therapeutics through combination therapy and the development of emerging approaches for the purification and delivery NK-Exo to severe immune and tumor cells and tissues were discussed in detail.
Databáze: Directory of Open Access Journals
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