Hepatoma‐derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival

Autor:	Jun Yang, Anjira S. Ambade, Melanie Nies, Megan Griffiths, Rachel Damico, Dhananjay Vaidya, Stephanie Brandal, Michael W. Pauciulo, Katie A. Lutz, Anna W. Coleman, William C. Nichols, Eric D. Austin, Dunbar Ivy, Paul M. Hassoun, Allen D. Everett
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	biomarker HDGF PAH vascular remodeling Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the respiratory system RC705-779
Zdroj:	Pulmonary Circulation, Vol 12, Iss 1, Pp n/a-n/a (2022)
Druh dokumentu:	article
ISSN:	2045-8940
DOI:	10.1002/pul2.12007
Popis:	Abstract Hepatoma‐derived growth factor (HDGF) was previously shown to be associated with increased mortality in a small study of idiopathic and connective tissue disease‐associated pulmonary arterial hypertension (PAH). In this study, we measured serum HDGF levels in a large multicenter cohort (total 2017 adult PAH‐Biobank enrollees), we analyzed the associations between HDGF levels and various clinical measures using linear or logistic regression models. Higher HDGF levels were found to be significantly associated with worse pulmonary hemodynamics, prostacyclin treatment; among PAH subtypes, higher HDGF levels were most associated with portopulmonary hypertension (beta = 0.469, p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f9c608c92ec340fa89eac873ca99df5e Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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