| Autor: |
Pedro I. Más-Bermejo, Félix O. Dickinson-Meneses, Kenia Almenares-Rodríguez, Lizet Sánchez-Valdés, Raúl Guinovart-Díaz, María Vidal-Ledo, Enrique Galbán-García, Yadira Olivera-Nodarse, Isabel Morgado-Vega, Santiago Dueñas-Carrera, Merardo Pujol, Francisco Hernández-Bernal, Miladys Limonta-Fernández, Gerardo Guillén-Nieto, Verena L. Muzio-González, Marta Ayala-Ávila |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
The Lancet Regional Health. Americas, Vol 16, Iss , Pp 100366- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2667-193X |
| DOI: |
10.1016/j.lana.2022.100366 |
| Popis: |
Summary: Background: COVID-19 vaccines have proven safe and efficacious in reducing severe illness and death. Cuban protein subunit vaccine Abdala has shown safety, tolerability and efficacy (92·3% [95% CI: 85·7‒95·8]) against SARS-CoV-2 in clinical trials. This study aimed to estimate Abdala's real-world vaccine effectiveness (VE). Methods: This retrospective cohort study in Havana analyzed Cuban Ministry of Public Health databases (May 12-August 31, 2021) to assess VE in preventing severe illness and death from COVID-19 (primary outcomes). Cox models accounting for time-varying vaccination status and adjusting by demographics were used to estimate hazard ratios. A subgroup analysis by age group and a sensitivity analysis including a subgroup of tested persons (qRT-PCR) were conducted. Daily cases and deaths were modelled accounting for different VE. Findings: The study included 1 355 638 persons (Mean age: 49·5 years [SD: 18·2]; 704 932 female [52·0%]; ethnicity data unavailable): 1 324 vaccinated (partially/fully) and 31 433 unvaccinated. Estimated VE against severe illness was 93·3% (95% CI: 92·1-94·3) in partially- vaccinated and 98·2% (95% CI: 97·9-98·5) in fully-vaccinated and against death was 94·1% (95% CI: 92·5-95·4) in partially-vaccinated and 98·7% (95% CI: 98·3-99·0) in fully-vaccinated. VE exceeded 92·0% in all age groups. Daily cases and deaths during the study period corresponded to a VE above 90%, as predicted by models. Interpretation: The Cuban Abdala protein subunit vaccine was highly effective in preventing severe illness and death from COVID-19 under real-life conditions. Funding: Cuban Ministry of Public Health. Genetic Engineering and Biotechnology Centre. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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