Lorazepam as a Cause of Drug-Induced Liver Injury
| Autor: | Toshio Arai, Kazutoyo Kogi, Yuki Honda, Takao Suzuki, Koji Kawai, Masako Okamoto, Takahiro Fujioka, Nobuhiro Murata |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Case Reports in Gastroenterology, Vol 12, Iss 2, Pp 546-550 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1662-0631 00049220 |
| DOI: | 10.1159/000492209 |
| Popis: | Lorazepam is a benzodiazepine derivative that is globally used for the therapy of anxiety and insomnia. A 51-year-old Japanese man with yellowish discoloration of the eyes and skin and pruritus was admitted due to liver dysfunction. He had taken lorazepam approximately 5 months prior to this admission. The clinical presentation and pathologic findings in the liver were consistent with drug-induced liver injury. After cessation of lorazepam, treatment with Stronger neo-minophagen C and ursodeoxycholic acid was started, and his liver injury resolved after 59 days. This case must serve as a warning to physicians to be aware of the possibility of unexpected liver injury caused by lorazepam. |
| Databáze: | Directory of Open Access Journals |
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